Amelioration of rat adjuvant-induced arthritis by Met-RANTES.

  title={Amelioration of rat adjuvant-induced arthritis by Met-RANTES.},
  author={Shiva Shahrara and Amanda E. I. Proudfoot and James M. Woods and Jeffrey H. Ruth and Mohammad A. Amin and Christy C. Park and Christian S Haas and Richard M. Pope and G. Kenneth Haines and Yuan yuan Zha and Alisa Erika Koch},
  journal={Arthritis and rheumatism},
  volume={52 6},
OBJECTIVE CC chemokines and their receptors play a fundamental role in trafficking and activation of leukocytes at sites of inflammation, contributing to joint damage in rheumatoid arthritis. Met-RANTES, an amino-terminal-modified methionylated form of RANTES (CCL5), antagonizes the binding of the chemokines RANTES and macrophage inflammatory protein 1alpha (MIP-1alpha; CCL3) to their receptors CCR1 and CCR5, respectively. The aim of this study was to investigate whether Met-RANTES could… CONTINUE READING
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Evaluation of a small molecule CCR2 antagonist in a rat model of rheumatoid arthritis [abstract]. Arthritis Rheum 2004;50 (Suppl 9):S369

  • CM Brodmerkel, R Collins, L Hall, D Hertel, R Stewart, A Wang
  • 2004
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