Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis.

@article{Suryavanshi2015AmeliorationOR,
  title={Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis.},
  author={Shweta Suryavanshi and Deepak Sharma and Rahul Checker and M. Thoh and Vikram Gota and Santosh K. Sandur and Krishna Balaji Sainis},
  journal={Free radical biology \& medicine},
  year={2015},
  volume={85},
  pages={
          56-70
        }
}
Hematopoietic stem cells and progenitor cells (HSPC) are low in abundance and exhibit high radiosensitivity and their ability to divide dramatically decreases following exposure to ionizing radiation. Our earlier studies have shown antiapoptotic, immune-stimulatory, and antioxidant effects of chlorophyllin, a constituent of the over the counter drug derifil. Here we describe the beneficial effects of chlorophyllin against radiation-induced hematopoietic syndrome. Chlorophyllin administration… Expand
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  • D. Li, Z. Tian, +5 authors F. Fan
  • Biology, Medicine
  • International journal of molecular sciences
  • 2016
TLDR
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The data suggest that XH‐105 is beneficial for the protection of radiation‐induced intestinal injury by inhibiting the p53‐dependent apoptosis signalling pathway. Expand
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