Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.

@article{Xavier2004AmeliorationOR,
  title={Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone.},
  author={Sandhya Xavier and Ester Piek and Makiko Fujii and Delphine Javelaud and Alain Mauviel and Kathy C Flanders and Ayelet M. Samuni and Angelina Felici and Michael Reiss and Shai Yarkoni and Anastasia L. Sowers and James B. Mitchell and Anita B. Roberts and Angelo Russo},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 15},
  pages={15167-76}
}
Radiation-induced fibrosis is an untoward effect of high dose therapeutic and inadvertent exposure to ionizing radiation. Transforming growth factor-beta (TGF-beta) has been proposed to be critical in tissue repair mechanisms resulting from radiation injury. Previously, we showed that interruption of TGF-beta signaling by deletion of Smad3 results in resistance to radiation-induced injury. In the current study, a small molecular weight molecule, halofuginone (100 nm), is demonstrated by… CONTINUE READING