Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

  title={Amelioration of progressive renal injury by genetic manipulation of Klotho gene.},
  author={Yoshisuke Haruna and Naoki Kashihara and Minoru Satoh and N. Miyoshi-G. Tomita and Tamehachi Namikoshi and Tamaki Sasaki and Toshihiko Fujimori and Zhanfeng Wang and Yashpal S. Kanwar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 7},
Klotho, an antiaging gene with restricted organ distribution, is mainly expressed in the kidney tubules; the mutant mice have shortened life span, arteriosclerosis, anemia, and osteoporesis, features common to patients with chronic renal failure. Conceivably, the reduction of the Klotho gene expression may contribute to the development of kidney failure; alternatively, its overexpression may lead to the amelioration of renal injury in an ICR-derived glomerulonephritis (ICGN) mouse model with… CONTINUE READING


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