Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction.

@article{Moleda2011AmeliorationOP,
  title={Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction.},
  author={Lukas Moleda and Jonel Trebicka and Peter Dietrich and Erwin Gaebele and Claus Hellerbrand and Rainer H Straub and Tilman Sauerbruch and Juergen Schoelmerich and Reiner Wiest},
  journal={Gut},
  year={2011},
  volume={60 8},
  pages={1122-32}
}
BACKGROUND Splanchnic vasodilation triggers the development of the hyperdynamic circulatory syndrome in portal hypertension. Neuropeptide Y (NPY), a sympathetic co-transmitter of norepinephrine, improves contractility in mesenteric arteries of pre-hepatic portal hypertensive rats. Therefore, we investigated the effect of NPY on mesenteric arterial contractility in vitro and in vivo in cirrhotic ascitic rats, as well as the vasoactive pathways involved. METHODS All experiments were performed… CONTINUE READING

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