Amelioration of oxidative stress in red blood cells from patients with β‐thalassemia major and intermedia and E‐β‐thalassemia following administration of a fermented papaya preparation

@article{Fibach2010AmeliorationOO,
  title={Amelioration of oxidative stress in red blood cells from patients with $\beta$‐thalassemia major and intermedia and E‐$\beta$‐thalassemia following administration of a fermented papaya preparation},
  author={Eitan Fibach and Ee Shien Tan and Saumya Shekhar Jamuar and Ivy Swee Lian Ng and Johnny Amer and Eliezer A. Rachmilewitz},
  journal={Phytotherapy Research},
  year={2010},
  volume={24}
}
In β‐hemoglobinopathies, such as β‐thalassemia (thal) and sickle cell anemia, the primary defects are mutations in the β‐globin gene. However, many aspects of the pathophysiology are mediated by oxidative stress. Fermented papaya preparation (FPP), a natural health food product obtained by biofermentation of carica papaya, has been shown to limit oxidative stress both in vitro and in vivo. We studied the effect of FPP on two groups of β‐thal patients: β‐thal, major and intermedia, (in Israel… 
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Oxidative status in the β-thalassemia syndromes in Sri Lanka; a cross-sectional survey.
Oxidative Stress in β-Thalassemia
TLDR
The role of oxidative stress and the current and potential antioxidative therapeutics in β-thalassemia are summarized and some methodologies, mostly cellular, that might be helpful for application of a theranostics approach to therapy are described.
The Clinical Effects of Fermented Papaya Preparation® (FPP®) on Oxidative Stress in Patients with HbE/ β -Thalassaemia
TLDR
Although oxidative stress parameters were decreased, FPP® did not have any significant effect on the Hb levels or QoL, and longer studies on larger sample size are required.
Fermented papaya preparation for β-thalassemia?
TLDR
A marked decrease in reactive oxygen species, lipid peroxidation and phosphatidylserine externalization and an increase in GSH were detected in both groups of patients, indicating that FPP is efficient in reducing the oxidative stress of these red blood cells.
Oxidative stress contributes to hemolysis in patients with hereditary spherocytosis and can be ameliorated by fermented papaya preparation
TLDR
Data indicate that oxidative stress plays an important role in the pathophysiology of HS which can be ameliorated by an antioxidant such as FPP, and additional clinical trials with FPP and other antioxidants are warranted.
HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics.
TLDR
An overview of HbE/β-thal disease with an emphasis on new findings pointing to pathophysiological mechanisms derived from and initiated by the dysfunctional property of H bE as a reduced nitrite reductase concomitant with excess α-chains exacerbating unstable Hb E, leading to a combination of nitric oxide imbalance, oxidative stress, and proinflammatory events.
The role of antioxidants and iron chelators in the treatment of oxidative stress in thalassemia
TLDR
It is concluded that oxidative stress plays a major role in the pathophysiology of thalassemia and other congenital and acquired hemolytic anemias and there is a rationale for iron chelation to eliminate the free‐iron species, which act like antioxidants.
Diet-Related Thalassemia Associated with Iron Overload
TLDR
Interestingly, functional natural products (such as mango, tea, caffeine, and curcumin), vegetables, and cereal are helpful for their health-providing properties by supplementing the endogenous antioxidant defensive power in the body.
Protein antioxidants in thalassemia.
Relationship between fermented papaya preparation supplementation, erythrocyte integrity and antioxidant status in pre-diabetics.
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