Amelioration of methotrexate-induced malabsorption by vitamin A

  title={Amelioration of methotrexate-induced malabsorption by vitamin A},
  author={J. Yamamoto and T. Horie and S. Awazu},
  journal={Cancer Chemotherapy and Pharmacology},
  • J. Yamamoto, T. Horie, S. Awazu
  • Published 1996
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • Abstract Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease… CONTINUE READING

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