Amelioration of methotrexate-induced malabsorption by vitamin A

@article{Yamamoto1996AmeliorationOM,
  title={Amelioration of methotrexate-induced malabsorption by vitamin A},
  author={Jun-ichi Yamamoto and Toshiharu Horie and Shoji Awazu},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1996},
  volume={39},
  pages={239-244}
}
Abstract Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease… 
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20 Citations

Effect of Vitamin A against Methotrexate-Induced Damage to the Small Intestine in Rats
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The results confirmed that administration of VA decreased the MTX-induced damage to the small intestine, and this protective effect of VA may have clinical applications in cancer chemotherapy.
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Results suggest that AGE may protect the small intestine of rats from antitumour drug-induced damage, and may even protect against damage from aged garlic extract.
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The administration of vitamin A before HDMTX may protect against drug-induced D-xylose malabsorption in children with cancer, and further studies are apparently needed to clarify the full benefits ofitamin A in preventingHDMTX-induced mucosal damage.
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Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate‐induced small intestinal damage in rats
TLDR
It is suggested thatTriphala unequal formulation provides significantly more protection than Triphala equal formulation against methotrexate‐induced damage in rat intestine.
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A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat
TLDR
It is concluded that MTX causes acute inflammatory changes with damage to the villi and crypts of lieberkhun that may result in decreased nutrient absorption associated with barrier and absorptive dysfunction of the small intestine.
Enhancement of glucose transport in small intestinal brush border membrane of retinol administered rat.
Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia
Purpose: To determine the antileukemic activity of weekly oral aminopterin in patients with refractory acute leukemia; to describe the pharmacodynamic properties of aminopterin; and to contrast the…
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References

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TLDR
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TLDR
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TLDR
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