Amelioration of methotrexate-induced malabsorption by vitamin A

@article{Yamamoto1996AmeliorationOM,
  title={Amelioration of methotrexate-induced malabsorption by vitamin A},
  author={Jun-ichi Yamamoto and Toshiharu Horie and Shoji Awazu},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1996},
  volume={39},
  pages={239-244}
}
Abstract Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease… 
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