Amelioration of methotrexate-induced malabsorption by vitamin A

  title={Amelioration of methotrexate-induced malabsorption by vitamin A},
  author={Jun-ichi Yamamoto and Toshiharu Horie and Shoji Awazu},
  journal={Cancer Chemotherapy and Pharmacology},
Abstract Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease… 
Effect of Vitamin A against Methotrexate-Induced Damage to the Small Intestine in Rats
The results confirmed that administration of VA decreased the MTX-induced damage to the small intestine, and this protective effect of VA may have clinical applications in cancer chemotherapy.
Alleviation by garlic of antitumor drug-induced damage to the intestine.
Results suggest that AGE may protect the small intestine of rats from antitumour drug-induced damage, and may even protect against damage from aged garlic extract.
Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats.
Results show that OP-1206 alleviates the methotrexate-induced damage to the small intestine of rats, using in vitro everted intestine and in situ intestinal loop techniques.
Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?
The administration of vitamin A before HDMTX may protect against drug-induced D-xylose malabsorption in children with cancer, and further studies are apparently needed to clarify the full benefits ofitamin A in preventingHDMTX-induced mucosal damage.
Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate‐induced small intestinal damage in rats
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Phase I and pharmacokinetic trial of aminopterin in patients with refractory malignancies.
  • A. Ratliff, J. Wilson, B. Kamen
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1998
It is concluded that AMT has good oral bioavailability and that, when given on a q12 hour x two weekly schedule, the maximum-tolerated dose (MTD) is 2 mg/m2 with delayed LV rescue.
A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat
It is concluded that MTX causes acute inflammatory changes with damage to the villi and crypts of lieberkhun that may result in decreased nutrient absorption associated with barrier and absorptive dysfunction of the small intestine.
Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia
Purpose: To determine the antileukemic activity of weekly oral aminopterin in patients with refractory acute leukemia; to describe the pharmacodynamic properties of aminopterin; and to contrast the


Vitamin A protects the small intestine from methotrexate-induced damage in rats.
It has been shown histologically, biochemically, physicochemical, physicochemically and physiologically that VA protects the small intestine from the damage induced by MTX.
Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.
Although the oral administration of MTX to rats inhibited DNA synthesis in crypt cells, VA coadministration protected the salvage pathway of pyrimidine synthesis and the de novo purine synthesis in Crypt cells.
Effect of methotrexate on drug absorption from the rat small intestine in situ and in vitro.
  • V. Venho
  • Medicine, Chemistry
    Acta pharmacologica et toxicologica
  • 1976
The methotrexate-induced reversible decrease in absorption seems to be attributable at least partly to diminished water flux through the intestinal wall, although other mechanisms may also exist.
The effect of oral methotrexate on the rat intestine.
Vitamin A, a useful biochemical modulator capable of preventing intestinal damage during methotrexate treatment.
Biochemical modulation used to prevent methotrexate-induced malabsorption by vitamin A coadministration will be of great use in metotrexate cancer chemotherapy.
Changes in the mucosa of the small intestine following methotrexate administration or abdominal x-irradiation.
  • G. Altmann
  • Medicine
    The American journal of anatomy
  • 1974
Adult male rats received 5 mg methotrexate daily and were sacrificed 1, 1.5, 2, 2.5 and 3 days after the beginning of the treatment. Other groups received 9,000 rads of abdominal x-radiation and were
Changes in D-glucose uptake by brush-border vesicles from small intestine of rats treated with mitomycin C.
Change in small intestinal brush border membranes of rats following methotrexate administration.
An apparent increase in the electronegative charge of brush border membrane vesicles per unit of membrane protein following methotrexate administration may possibly cause the change in fluorescence spectra and polarization of safranin 0.1.