Amelioration of methotrexate-induced malabsorption by vitamin A
@article{Yamamoto1996AmeliorationOM, title={Amelioration of methotrexate-induced malabsorption by vitamin A}, author={Jun-ichi Yamamoto and Toshiharu Horie and Shoji Awazu}, journal={Cancer Chemotherapy and Pharmacology}, year={1996}, volume={39}, pages={239-244} }
Abstract Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease…
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Effect of Vitamin A against Methotrexate-Induced Damage to the Small Intestine in Rats
- MedicineMedical Principles and Practice
- 2004
The results confirmed that administration of VA decreased the MTX-induced damage to the small intestine, and this protective effect of VA may have clinical applications in cancer chemotherapy.
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Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats.
- Biology, MedicineJournal of pharmaceutical sciences
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Results show that OP-1206 alleviates the methotrexate-induced damage to the small intestine of rats, using in vitro everted intestine and in situ intestinal loop techniques.
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The administration of vitamin A before HDMTX may protect against drug-induced D-xylose malabsorption in children with cancer, and further studies are apparently needed to clarify the full benefits ofitamin A in preventingHDMTX-induced mucosal damage.
A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats.
- Medicine, BiologyLife sciences
- 2002
Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate‐induced small intestinal damage in rats
- BiologyPhytotherapy research : PTR
- 2009
It is suggested thatTriphala unequal formulation provides significantly more protection than Triphala equal formulation against methotrexate‐induced damage in rat intestine.
Phase I and pharmacokinetic trial of aminopterin in patients with refractory malignancies.
- MedicineJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 1998
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- Biology, Medicine
- 2011
It is concluded that MTX causes acute inflammatory changes with damage to the villi and crypts of lieberkhun that may result in decreased nutrient absorption associated with barrier and absorptive dysfunction of the small intestine.
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- Biology, ChemistryLife sciences
- 1999
Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia
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Purpose: To determine the antileukemic activity of weekly oral aminopterin in patients with refractory acute leukemia; to describe the pharmacodynamic properties of aminopterin; and to contrast the…
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