Amelioration of methotrexate-induced malabsorption by vitamin A

@article{Yamamoto1996AmeliorationOM,
  title={Amelioration of methotrexate-induced malabsorption by vitamin A},
  author={Jun-ichi Yamamoto and Toshiharu Horie and Shoji Awazu},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1996},
  volume={39},
  pages={239-244}
}
Abstract Methotrexate (MTX) induces damage to the small intestine, resulting in malabsorption and diarrhea. We found that the coadministration of vitamin A (VA) with MTX protected the small intestine from MTX-induced damage. In this study, the permeability of D-glucose, D-xylose and L-leucine through the small intestine of rats treated with MTX and/or VA was studied using everted segments of small intestine. MTX treatment decreased permeability and VA coadministration prevented the decrease… Expand
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Effect of Vitamin A against Methotrexate-Induced Damage to the Small Intestine in Rats
TLDR
The results confirmed that administration of VA decreased the MTX-induced damage to the small intestine, and this protective effect of VA may have clinical applications in cancer chemotherapy. Expand
Correlation between methotrexate-induced intestinal damage and decrease in polyamine content.
TLDR
It is indicated that OP-1206 could protect the intestinal mucosa against the biochemical effects of MTX through a trophic action on intestinal villi. Expand
Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.
TLDR
DHA protected the small intestine of mice from theMTX-induced damage and the permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester protected thesmall intestine from the increase in the small intestinal permeability. Expand
Evaluation of damaged small intestine of mouse following methotrexate administration
TLDR
Evaluating the damage to the small intestine of mice caused by MTX administration revealed that MTX treatment disorders the paracellular barrier function of the small intestinal epithelium, resulting in increased permeation of nonabsorbable markers via the parACEllular pathway of theSmall intestinal mucosa. Expand
Alleviation by garlic of antitumor drug-induced damage to the intestine.
TLDR
Results suggest that AGE may protect the small intestine of rats from antitumour drug-induced damage, and may even protect against damage from aged garlic extract. Expand
Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats.
TLDR
Results show that OP-1206 alleviates the methotrexate-induced damage to the small intestine of rats, using in vitro everted intestine and in situ intestinal loop techniques. Expand
Changes in intestinal absorption of 5-fluorouracil-treated rats.
TLDR
The administration of 5-fluorouracil to rats caused body weight loss and epithelial barrier dysfunction of the small intestine in rats as shown by the increased permeation of the high molecular weight compound, fluorescein isothiocyanate-labelled dextran. Expand
Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?
TLDR
The administration of vitamin A before HDMTX may protect against drug-induced D-xylose malabsorption in children with cancer, and further studies are apparently needed to clarify the full benefits ofitamin A in preventingHDMTX-induced mucosal damage. Expand
A synthetic analog of prostaglandin E(1) prevents the production of reactive oxygen species in the intestinal mucosa of methotrexate-treated rats.
TLDR
OP-1206 may possibly help the anticancer chemotherapy by protecting the small intestine from the methotrexate-induced damage. Expand
Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate‐induced small intestinal damage in rats
TLDR
It is suggested thatTriphala unequal formulation provides significantly more protection than Triphala equal formulation against methotrexate‐induced damage in rat intestine. Expand
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References

SHOWING 1-10 OF 22 REFERENCES
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TLDR
It has been shown histologically, biochemically, physicochemical, physicochemically and physiologically that VA protects the small intestine from the damage induced by MTX. Expand
Protective effect of vitamin A against the methotrexate-induced damage to small intestine: a study on the crypt cells.
TLDR
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TLDR
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TLDR
Biochemical modulation used to prevent methotrexate-induced malabsorption by vitamin A coadministration will be of great use in metotrexate cancer chemotherapy. Expand
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TLDR
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TLDR
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TLDR
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