Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure.

@article{Salem2010AmeliorationOG,
  title={Amelioration of gentamicin nephrotoxicity by green tea extract in uninephrectomized rats as a model of progressive renal failure.},
  author={Emad A. Salem and Neveen A Salem and Mostafa Kamel and Aref M. Maarouf and Nabil K. Bissada and Wayne J. G. Hellstrom and Mohmoud Eladl},
  journal={Renal failure},
  year={2010},
  volume={32 10},
  pages={1210-5}
}
RATIONALE Gentamicin (GM) is an effective antibiotic against severe infection but has limitations related to nephrotoxicity. This study investigates whether green tea extract (GTE), an antioxidant, could ameliorate the nephrotoxic effect of GM in uninephrectomized rats. OBJECTIVES The right kidneys of 40 rats were surgically removed and 1 week later the animals were divided into four groups (n = 10). Group 1 served as control, Group 2 as GTE group, Group 3 as GM group, and Group 4 as GM+GTE… CONTINUE READING
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