Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma.

@article{Niino2001AmeliorationOE,
  title={Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma.},
  author={M Niino and Kazuya Iwabuchi and Seiji Kikuchi and Manabu Ato and Taiki Morohashi and Aya Ogata and Kazuhiro Tashiro and Kyuichiro Onoe},
  journal={Journal of neuroimmunology},
  year={2001},
  volume={116 1},
  pages={40-8}
}
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, plays a critical role in adipocyte differentiation and glucose homeostasis. It has been implicated that PPAR-gamma functions as a regulator of cellular proliferation and inflammatory responses. In the present study, we examined whether troglitazone, a selective PPAR-gamma agonists, ameliorated experimental autoimmune encephalomyelitis (EAE) induced by administration of myelin… CONTINUE READING
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