Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro.

@article{Yoshifuji2005AmeliorationOE,
  title={Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro.},
  author={Hajime Yoshifuji and Hisanori Umehara and Hidenori Maruyama and Mari Itoh and Masao Tanaka and Daisuke Kawabata and Takao Fujii and Tsuneyo Mimori},
  journal={International immunology},
  year={2005},
  volume={17 10},
  pages={1327-36}
}
Calpain, a calcium-dependent cysteine proteinase, has been reported to participate in the pathophysiology of rheumatoid arthritis (RA). The aim of this study is to investigate the therapeutic efficacy of calpain-inhibitory compounds in an animal model of RA and to clarify the underlying mechanisms in vivo and in vitro. Arthritis was induced in BALB/c mice with anti-type II collagen mAbs and LPS, and the mice were treated intra-peritoneally with a high dose (9 mg kg(-1) per day) or low dose (3… CONTINUE READING