Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy.

@article{Heaton2000AmeliorationOE,
  title={Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy.},
  author={Marieta Barrow Heaton and J. Jean Mitchell and Michael S Paiva},
  journal={Alcoholism, clinical and experimental research},
  year={2000},
  volume={24 4},
  pages={512-8}
}
BACKGROUND The cerebellum of the neonatal rat is highly susceptible to ethanol, with profound loss of Purkinje cells resulting from even brief exposure during the first postnatal week. Developmental ethanol exposure previously has been shown to induce free radicals/oxidative stress processes and/or down-regulate protective antioxidants. In an earlier study, we found antioxidants protected against ethanol neurotoxicity in a tissue culture environment. The present study was designed to determine… CONTINUE READING