Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

@article{Zaba2008AmeliorationOE,
  title={Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses},
  author={Lisa C. Zaba and I. Cardinale and P. Gilleaudeau and M. Sullivan-Whalen and M. Su{\'a}rez-Fari{\~n}as and J. Fuentes-Duculan and I. Novitskaya and A. Khatcherian and M. Bluth and M. Lowes and J. Krueger},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={1941 - 1941}
}
3183 Psoriasis is a common autoimmune skin disease aff ecting 1 – 2% of the population in North America and Europe. Over the years, psoriasis has been considered either a primary disease of keratinocytes or of T cells, with a strong genetic component (1). Until recently, IFN-␥ – producing Th1 cells were implicated as the main patho-genic cells (2), as certain T cell – targeted therapies were successful in clearing psoriasis (1), and clonal T cells have been found in psoriatic skin (3). However… Expand

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References

SHOWING 1-10 OF 50 REFERENCES
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.
TLDR
A crucial role for alpha1beta1 is defined in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment focusing on T cell-extracellular matrix interactions. Expand
Comparative analysis of colonic gene expression of three experimental colitis models mimicking infl ammatory bowel disease. Infl amm. Bowel Dis
  • Comparative analysis of colonic gene expression of three experimental colitis models mimicking infl ammatory bowel disease. Infl amm. Bowel Dis
  • 2007
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal infl ammation and acanthosis
  • Nature
  • 2007
New concepts in the pathogenesis and treatment of psoriasis: key roles for IL-23, IL-17A and TGF-β1
TLDR
If psoriasis is proven to be a Th17 disease and not a Th1 disease, these cytokines will be attractive targets for future therapies for individuals with Psoriasis. Expand
Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages.
TLDR
The normal dermis of normal human skin contains typical immunostimulatory myeloid DCs identified by CD11c and BDCA-1, as well as an additional population of poorly stimulatory macrophages marked by CD163 and FXIIIA. Expand
Pathogenesis and therapy of psoriasis
TLDR
The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases. Expand
Phenotypic and functional features of human Th17 cells
TLDR
The demonstration of selective markers for human Th17 cells may help to understand their pathogenic role, and the identification of a subset of cells sharing features of both Th1 and Th17 may raise new issues concerning developmental and/or functional relationships between Th17 and Th1. Expand
Phenotypic diff erences between Th1 and Th17 cells and negative regulation of Th1 cell diff erentiation by IL-17
  • J. Leukoc. Biol
  • 2007
TH-17 cells in the circle of immunity and autoimmunity
TLDR
New data suggest a dichotomy between CD4+ regulatory T cells positive for the transcription factor Foxp3 and TH-17 cells, whereas IL-6 inhibits TGF-β-driven Foxp 3 expression and together with T GF-β induces TH- 17 cells. Expand
The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis
TLDR
It is shown that primary human keratinocytes express receptors for these cytokines and that IL-20 subfamily cytokines induce acanthosis in reconstituted human epidermis (RHE) in a dose-dependent manner. Expand
...
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2
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4
5
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