Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids.

  title={Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids.},
  author={R. V. Madhumitha Indu and Tahmina Azhar and Arathy G. Nair and Cherupally Krishnan Krishnan Nair},
  journal={Journal of cancer research and therapeutics},
  volume={10 1},
  • R. InduT. Azhar C. Nair
  • Published 2014
  • Medicine, Biology, Chemistry
  • Journal of cancer research and therapeutics
AIM OF STUDY The aim of this study is to explore the ability of the carotenoids (CARs) to offer protection against acute cardiotoxicity and hepatotoxicity induced by doxorubicin (DOX) (25 mg/kg) in tumor bearing Swiss albino mice. MATERIALS AND METHODS Tumor bearing Swiss albino mice administered with DOX (25 mg/kg, i.p) and two doses of CARs (50 and 100 μg/kg). 24 h after administration of the drugs, histopathological evaluation of tumor, liver and heart tissues carried out. Furthermore… 

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