Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB.

@article{Venkatraman2003AmeliorationOD,
  title={Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB.},
  author={Aparna Venkatraman and Balakrishnan Siddharth Ramakrishna and Ramachandran Velayudhan Shaji and N. S. Nanda Kumar and Anna Pulimood and Susama Patra},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={285 1},
  pages={
          G177-84
        }
}
Butyrate enemas have been demonstrated to ameliorate inflammation in ulcerative colitis. The mechanism of this protective effect of butyrate is not known, and this study examines the effect of butyrate on epithelial function, inducible heat shock protein 70 (HSP70) expression, and NF-kappaB activation in experimental colitis. Colitis was induced in rats by oral dextran sulfate sodium (DSS) and by butyrate or saline enemas. Mucosal barrier function was assessed by electrical resistance and [14C… CONTINUE READING

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