Amelioration of cisplatin-induced toxicity in mice by carotenoid meso-zeaxanthin.


Carotenoid meso-zeaxanthin ((3R, 3'S)-β, β-carotene-3,3'-diol [MZ]) was evaluated for its protective effect against cisplatin-induced nephrotoxicity in Swiss albino mice. Oral administration of MZ was started 5 days prior to cisplatin (16 mg/kg body weight, intraperitoneally as a single dose) injection. Animals in all groups were killed 72 h after cisplatin… (More)
DOI: 10.1177/0960327111431707