Amelioration of cholinergic neurons dysfunction in aged rats depends on the continuous supply of NGF.

@article{Niewiadomska2002AmeliorationOC,
  title={Amelioration of cholinergic neurons dysfunction in aged rats depends on the continuous supply of NGF.},
  author={Grażyna Niewiadomska and Sebastian Komorowski and Marta Baksalerska-Pazera},
  journal={Neurobiology of aging},
  year={2002},
  volume={23 4},
  pages={601-13}
}
The present study was designed to examine whether NGF-induced improvement in morphology of senile basal forebrain cholinergic neurons persist after discontinuation of NGF treatment. Trophic effect of continuous intraventricular infusion of NGF was tested in the 4- and 28 months old male Wistar rats immediately after cessation of NGF and 3 or 6 weeks after termination of treatment. Immunohistochemical procedure for ChAT, TrkA, and p75(NTR) receptor has been applied to identify cholinergic cells… CONTINUE READING

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