Amelioration of cardiodepressive effects of gadopentetate dimeglumine with addition of ionic calcium.

@article{Mhler1992AmeliorationOC,
  title={Amelioration of cardiodepressive effects of gadopentetate dimeglumine with addition of ionic calcium.},
  author={Andreas M{\"u}hler and Maythem Saeed and Robert C. Brasch and Charles Higgins},
  journal={Radiology},
  year={1992},
  volume={184 1},
  pages={159-64}
}
Doses of gadopentetate dimeglumine of 0.1-0.5 mmol/kg cause cardiodepressive effects when injected as a rapid central bolus into the left jugular vein. This study evaluated the hemodynamic effects of this magnetic resonance imaging contrast medium with and without calcium supplementation in a rat model. Also, the potential of gadopentetate dimeglumine to bind ionized serum calcium was investigated in vitro. Addition of calcium ions resulted in dose-dependent attenuation of the hemodynamic… CONTINUE READING
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