Amelioration of autoimmune nephritis by imatinib in MRL/lpr mice.

  title={Amelioration of autoimmune nephritis by imatinib in MRL/lpr mice.},
  author={Atsushi Sadanaga and Hitoshi Nakashima and Kohsuke Masutani and Katsuhisa Miyake and Sakiko Shimizu and Takashi Igawa and Naonobu Sugiyama and Hiroaki Niiro and Hideki Hirakata and M. D. N. Harada},
  journal={Arthritis and rheumatism},
  volume={52 12},
OBJECTIVE To examine whether the platelet-derived growth factor (PDGF) receptor antagonist imatinib ameliorates glomerulonephritis in MRL/lpr mice, a condition that is similar to severe lupus nephritis in humans. METHODS Sixteen-week-old MRL/lpr female mice having an advanced stage of glomerulonephritis were divided into 3 groups according to treatment: 1) 50 mg/kg or 2) 10 mg/kg of imatinib (administered orally 4 times a week up to 24 weeks of age) or 3) vehicle solution (untreated group… CONTINUE READING

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