Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice

@article{Keshavarz2018AmeliorationOP,
  title={Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice},
  author={M. Keshavarz and Behdad Yekzaman},
  journal={Iranian Journal of Medical Sciences},
  year={2018},
  volume={43},
  pages={195 - 201}
}
Background Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol. Methods PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8… Expand
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