Amelioration of Experimental Autoimmune Encephalomyelitis by β-elemene Treatment is Associated with Th17 and Treg Cell Balance

@article{Zhang2010AmeliorationOE,
  title={Amelioration of Experimental Autoimmune Encephalomyelitis by β-elemene Treatment is Associated with Th17 and Treg Cell Balance},
  author={Rongwei Zhang and Ayong Tian and Huimin Zhang and Zhike Zhou and Hongmei Yu and Lei Chen},
  journal={Journal of Molecular Neuroscience},
  year={2010},
  volume={44},
  pages={31-40}
}
Experimental autoimmune encephalomyelitis (EAE), an animal mode of multiple sclerosis (MS), was previously considered that is mediated by Th1 cells. However, a number of recent studies provided strong evidence that T helper cells that produce interleukin (IL)-17 (Th17) and anti-inflammatory CD4+ Foxp3+ regulatory T cells (Tregs) play a dominant role in the pathogenesis of EAE. β-elemene is a natural antitumor plant drug with the role of multiple target, and it has been found to pass through the… CONTINUE READING
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