Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat

@inproceedings{Takahashi2012AmeliorationOA,
  title={Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat},
  author={Kazunori Takahashi and Hiroki Mizukami and Kosuke Kamata and Wataru Inaba and Noriaki Kato and Chihiro Hibi and Soroku Yagihashi},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Systemic inflammatory response syndrome is a fatal disease because of multiple organ failure. Acute kidney injury is a serious complication of systemic inflammatory response syndrome and its genesis is still unclear posing a difficulty for an effective treatment. Aldose reductase (AR) inhibitor is recently found to suppress lipopolysaccharide (LPS)-induced cardiac failure and its lethality. We studied the effects of AR inhibitor on LPS-induced acute kidney injury and its mechanism… CONTINUE READING

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