Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion.

@article{Han2008AmelioratingEO,
  title={Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion.},
  author={Jing-Yan Han and Jing-yu Fan and Yoshinori Horie and Soichiro Miura and De-hua Cui and Hiromasa Ishii and Toshifumi Hibi and Hiroshi Tsuneki and Ikuko Kimura},
  journal={Pharmacology & therapeutics},
  year={2008},
  volume={117 2},
  pages={
          280-95
        }
}
Ischemia and reperfusion (I/R) exerts multiple insults in microcirculation, frequently accompanied by endothelial cell injury, enhanced adhesion of leukocytes, macromolecular efflux, production of oxygen free radicals, and mast cell degranulation. Since the microcirculatory disturbance results in injury of organ involved, protection of organ after I/R is of great importance in clinic. Salvia miltiorrhiza root has long been used in Asian countries for clinical treatment of various… CONTINUE READING

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