Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis.

@article{Totsuka2003AmelioratingEO,
  title={Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis.},
  author={Teruji Totsuka and T. Hosokawa Kanai and Ryoichi Iiyama and Koji Uraushihara and Motomi Yamazaki and Ryuichi Okamoto and Toshifumi Hibi and Katsunari Tezuka and Miyuki Azuma and Hisaya Akiba and H. Yagita and Ko Okumura and Mamoru Watanabe},
  journal={Gastroenterology},
  year={2003},
  volume={124 2},
  pages={410-21}
}
BACKGROUND & AIMS Inducible costimulator (ICOS)/B7RP-1 represents a newly described receptor/ligand pair involved in costimulation of T cells by antigen-presenting cells. We investigated the involvement of the ICOS/B7RP-1 interaction in the pathogenesis of colitis and the therapeutic potential of anti-ICOS monoclonal antibody (mAb) in experimental colitis METHODS We administered anti-ICOS or anti-B7RP-1 mAb to mice with experimental colitis induced by transfer of CD4(+)CD45RB(high) T cells… CONTINUE READING

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