• Medicine
  • Published in
    Iranian journal of kidney…
    2015

Ameliorating effect of Klotho on endoplasmic reticulum stress and renal fibrosis induced by unilateral ureteral obstruction.

@article{Liu2015AmelioratingEO,
  title={Ameliorating effect of Klotho on endoplasmic reticulum stress and renal fibrosis induced by unilateral ureteral obstruction.},
  author={Qi-feng Liu and Jian-ming Ye and Zhi-yong Deng and Li-xia Yu and Qiang Sun and Sha-Sha Li},
  journal={Iranian journal of kidney diseases},
  year={2015},
  volume={9 4},
  pages={
          291-7
        }
}
INTRODUCTION Expression of Klotho is decreased and endoplasmic reticulum (ER) stress is activated in patients with chronic kidney disease. This study aimed to investigate the effect of Klotho protein on ER stress-related apoptosis and renal fibrosis in rates with unilateral ureteral obstruction (UUO). MATERIALS AND METHODS Twenty-four rats were divided into the sham, UUO, and Klotho treatment groups. Renal interstitial fibrosis model was induced by UUO in the rats of the latter two groups… CONTINUE READING

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