Amdinocillin (Mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of Escherichia coli.

@article{Thulin2015AmdinocillinR,
  title={Amdinocillin (Mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of Escherichia coli.},
  author={Elisabeth Thulin and Martin Sundqvist and Dan I Andersson},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 3},
  pages={
          1718-27
        }
}
Amdinocillin (mecillinam) is a β-lactam antibiotic that is used mainly for the treatment of uncomplicated urinary tract infections. The objectives of this study were to identify mutations that confer amdinocillin resistance on laboratory-isolated mutants and clinical isolates of Escherichia coli and to determine why amdinocillin resistance remains rare clinically even though resistance is easily selected in the laboratory. Under laboratory selection, frequencies of mutation to amdinocillin… CONTINUE READING
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