Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053).

@article{Appleton2017AmbulancedeliveredTG,
  title={Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053).},
  author={Jason Philip Appleton and Polly Scutt and Mark B. Dixon and Harriet Howard and Lee Haywood and Diane Havard and Trish Hepburn and Tim England and Nikola Sprigg and Lisa J Woodhouse and Joanna M. Wardlaw and Alan A Montgomery and Stuart J. Pocock and Philip M Bath},
  journal={International journal of stroke : official journal of the International Stroke Society},
  year={2017},
  pages={1747493017724627}
}
Rationale Vascular nitric oxide levels are low in acute stroke and donors such as glyceryl trinitrate have shown promise when administered very early after stroke. Potential mechanisms of action include augmentation of cerebral reperfusion, thrombolysis and thrombectomy, lowering blood pressure, and cytoprotection. Aim To test the safety and efficacy of… CONTINUE READING