Ambovex® as a novel immunological modulator drug for the treatment of hepatocellular carcinoma (HCC) in the liver: a Phase II clinical trial

@article{Salama2015AmbovexAA,
  title={Ambovex{\textregistered} as a novel immunological modulator drug for the treatment of hepatocellular carcinoma (HCC) in the liver: a Phase II clinical trial},
  author={Hosny Salama and Hassan Ahmad and Ismail Elchagea and A. Zekri and Eman Medhat and Abeer A Bahnassy and Michael Lange and M S Rabbat and Andrew de la Torre and Pravin Punamiya},
  journal={Journal of Hepatocellular Carcinoma},
  year={2015},
  volume={2},
  pages={79 - 89}
}
Hepatocellular carcinoma (HCC) is a global public health problem, based on it being the fifth most common cancer and third leading cause of cancer-related mortality worldwide. The approved conventional treatment methods for HCC have shown life-threatening side effects with limited or negligible success, especially in multifocal HCC. As a consequence, new therapeutic approaches are being explored, including immunoregulatory molecules that may have the potential to treat or delay the progression… 
1 Citations

Figures and Tables from this paper

Editorial: charting the future of hepatocellular carcinoma publications
  • A. Kaseb
  • Medicine
    Journal of hepatocellular carcinoma
  • 2018
TLDR
This work is licensed to www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License, which is permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

References

SHOWING 1-10 OF 45 REFERENCES
Sorafenib in advanced hepatocellular carcinoma.
TLDR
The assay used for detection of anti-adalimumab antibodies in this trial was an enzyme-linked immunosorbent assay that has been used for more than 11 years in the adalimumab-development program and it has been accepted by regulatory agencies worldwide.
Current Treatment Modalities for Hepatocellular Carcinoma
TLDR
Surgical resection in the form of partial or total hepatectomy is the preferred treatment for HCC and Randomized trials of combinations of chemotherapy and surgical resection are needed to demonstrate their potential utity for treatment.
Treatment of small hepatocellular carcinoma in cirrhotic patients: A cohort study comparing surgical resection and percutaneous ethanol injection
TLDR
It is confirmed that ethanol injection is a useful treatment for patients with solitary small hepatocellular carcinomas and suggest that surgical resection and liver transplantation may achieve better results only after strict candidate selection to reduce mortality and tumor recurrence during follow‐up.
Antigen Processing and Presentation in the Liver
TLDR
The liver is an important site of infectious, parasitic, autoimmune, and malignant diseases and appears to play an important role in the induction of oral tolerance, as well as in the development/persistence of certain viral infections and cancer.
Hepatocellular carcinoma: epidemiology and clinical aspects.
Clinical presentation, diagnostic work-up and therapeutic choices in two consecutive series of patients with hepatocellular carcinoma.
TLDR
The percentage of multiple tumours was comparable in two series implying the presence of two kinds of HCC, different ¿ab initio' and the survival rate of untreated patients was better in the second series.
Elevated serum levels of soluble Fas/APO‐1 (CD95) in patients with hepatocellular carcinoma
  • Jodo, Kobayashi, Koike
  • Medicine, Biology
    Clinical and experimental immunology
  • 1998
Fas (APO‐1/CD95)‐mediated apoptosis plays an important role in liver cell destruction in viral hepatitis. Using sandwich ELISA, we measured serum levels of soluble Fas (sFas) in patients with
Comparison of hepatectomy and transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma: Necessity for prospective randomized trial
TLDR
A prospective study is warranted to elucidate whether hepatectomy or transcatheter arterial chemoembolization is more effective for treating resectable hepatocellular carcinoma associated with cirrhosis.
Hepatocellular carcinoma: one of the world's most common malignancies.
  • G. Cook
  • Medicine, Biology
    The Quarterly journal of medicine
  • 1985
TLDR
There is a geographical correlation between hepatocellular carcinoma and the HBsAg carrier state, and the role of non-A non-B virus infections in the production of chronic liver disease is clear, but without serological markers their importance in hepatitis B virus infections is unknown.
General management.
  • M. Nguyen, E. Keeffe
  • Medicine, Biology
    Best practice & research. Clinical gastroenterology
  • 2005
TLDR
The role of biopsy, the pros and cons of noninvasive and pathologic tissue diagnosis as well as the general approach to choose the most appropriate treatment for patients with hepatocellular carcinoma are discussed.
...
...