Amblyopia: Challenges and Opportunities The Lasker/IRRF Initiative for Innovation in Vision Science

  title={Amblyopia: Challenges and Opportunities The Lasker/IRRF Initiative for Innovation in Vision Science},
  author={Elizabeth M. Quinlan and Peter D. Lukasiewicz},
  journal={Visual Neuroscience},
The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation is the canonical model of synaptic plasticity confined to a postnatal critical period. Developmental constraints on this plasticity not only lend stability to the mature visual cortical circuitry but also impede the ability to recover from amblyopia beyond an early window. Advances with mouse models utilizing the power of molecular, genetic, and imaging tools are beginning to unravel the circuit, cellular… 

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