Amblyopia: Challenges and Opportunities The Lasker/IRRF Initiative for Innovation in Vision Science

@article{Quinlan2018AmblyopiaCA,
  title={Amblyopia: Challenges and Opportunities The Lasker/IRRF Initiative for Innovation in Vision Science},
  author={Elizabeth M. Quinlan and Peter D. Lukasiewicz},
  journal={Visual Neuroscience},
  year={2018},
  volume={35}
}
The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation is the canonical model of synaptic plasticity confined to a postnatal critical period. Developmental constraints on this plasticity not only lend stability to the mature visual cortical circuitry but also impede the ability to recover from amblyopia beyond an early window. Advances with mouse models utilizing the power of molecular, genetic, and imaging tools are beginning to unravel the circuit, cellular… 
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Background Citations
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Methods Citations
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8 Citations

Correction of amblyopia in cats and mice after the critical period

It is shown in cats and mice that temporary inactivation of the fellow eye is sufficient to promote a full and enduring recovery from amblyopia at ages when conventional treatments fail, and connections serving the amblyopic eye are capable of substantial plasticity beyond the critical period.

Impact of Amblyopia on the Central Nervous System

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Vision Disorders and Visual Impairment

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A school-based screening programme correctly identified 84% of those kindergarten children who were found to have a visual problem by a cyclopleged optometry exam, revealing how accuracy varies with different combinations of screening tools and referral criteria.

Optimizing Visual Cortex Parameterization with Error-Tolerant Teichmuller Map in Retinotopic Mapping

An integrated approach that parameterizes the cortical surface, such that the parametric coordinates linearly relates the visual coordinate is proposed, which helps the smoothing of noisy retinotopic maps and obtains neurophysiological insights in human vision systems.

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