Amblyopia: Challenges and Opportunities The Lasker/IRRF Initiative for Innovation in Vision Science

@article{Quinlan2018AmblyopiaCA,
  title={Amblyopia: Challenges and Opportunities The Lasker/IRRF Initiative for Innovation in Vision Science},
  author={E. Quinlan and P. Lukasiewicz},
  journal={Visual Neuroscience},
  year={2018},
  volume={35}
}
The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation is the canonical model of synaptic plasticity confined to a postnatal critical period. Developmental constraints on this plasticity not only lend stability to the mature visual cortical circuitry but also impede the ability to recover from amblyopia beyond an early window. Advances with mouse models utilizing the power of molecular, genetic, and imaging tools are beginning to unravel the circuit, cellular… Expand
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6 Citations

6 Citations

Citation Type

Citation Type

Impact of Amblyopia on the Central Nervous System
TLDR
There is some evidence that amblyopia’s impact on the CNS depends on its etiology, with different patterns of results for strabismic and anisometropic amblyopes, and simultaneous collection of retinal, neural, and perceptual measures should be employed. Expand
Optimizing Visual Cortex Parameterization with Error-Tolerant Teichmuller Map in Retinotopic Mapping
TLDR
An integrated approach that parameterizes the cortical surface, such that the parametric coordinates linearly relates the visual coordinate is proposed, which helps the smoothing of noisy retinotopic maps and obtains neurophysiological insights in human vision systems. Expand
Binocular Summation and Suppression of Contrast Sensitivity in Strabismus, Fusion and Amblyopia
TLDR
It is concluded that monocular and binocular contrast sensitivity deficits define important characteristics of amblyopia and strabismus that are not captured by visual acuity alone and can be measured efficiently using the quick CSF. Expand
Feasibility of a school-based vision screening program to detect undiagnosed visual problems in kindergarten children in Ontario
TLDR
It is found that in-school vision screening with follow-up eye examinations is an effective strategy for identifying at-risk children and placing them in eye care before grade 1. Expand
Comparison of 2Win and plusoptiX A12R refractometers with Retinomax handheld autorefractor keratometer.
TLDR
In manifest conditions, the accuracy of the 2Win and plusoptiX A12R refractometers is low in hyperopia and astigmatism, but the devices are well correlated with each other, and both have high specificity and low sensitivity inhyperopia, resulting in the underestimation of hyperopic refractive error. Expand
Choosing appropriate tools and referral criteria for vision screening of children aged 4–5 years in Canada: a quantitative analysis
TLDR
A school-based screening programme correctly identified 84% of those kindergarten children who were found to have a visual problem by a cyclopleged optometry exam, revealing how accuracy varies with different combinations of screening tools and referral criteria. Expand

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