Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell

@inproceedings{Morais2016AmblyominXIE,
  title={Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell},
  author={K{\'a}tia L. P. Morais and M{\'a}rio Thiego Fernandes Pacheco and C. M. Berra and Rosemary Viola Bosch and Juliana Mozer Sciani and Roger Chammas and Renata de Freitas Saito and Asif Iqbal and Ana Marisa Chudzinski-Tavassi},
  booktitle={Molecular and Cellular Biochemistry},
  year={2016}
}
During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a Kunitz-type FXa inhibitor similar to endogenous tissue factor pathway inhibitor (TFPI) and is a novel proteasome inhibitor. Herein, we have demonstrated Amblyomin-X cytotoxicity… CONTINUE READING