Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?

  title={Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?},
  author={Kate E Lawlor and James Edward Vince},
  journal={Biochimica et biophysica acta},
  volume={1840 4},
BACKGROUND The NLRP3 inflammasome is a sensor of specific pathogen, host and environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves and thereby activates precursor interleukin-1β (IL-1β) and IL-18 to initiate immune responses. Several recent studies have posited that the mitochondria are a central regulator of NLRP3 function. SCOPE OF REVIEW Mitochondrial reactive oxygen species (mtROS) production, mitochondrial apoptosis, mitochondrial DNA (mtDNA) release… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 33 extracted citations


Publications referenced by this paper.
Showing 1-10 of 112 references


S. Wang, M. Miura, Y. K. Jung, H. Zhu
Li, et al., Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE, Cell 92 (1998) 501–509. 1439 K.E. Lawlor, J.E. Vince / Biochimica et Biophysica Acta 1840 • 2014
View 1 Excerpt
Highly Influenced


M. Rossol, M. Pierer, N. Raulien, D. Quandt
Meusch, et al., Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors, Nat. Commun. 3 • 2012
View 6 Excerpts
Highly Influenced

AIM 2 / ASC triggers caspase8dependent apoptosis in Francisellainfected caspase1de fi cient macrophages

P. Mangeot
Cell Death Differ . • 2013

Similar Papers

Loading similar papers…