Ambient temperature modulation of fenfluramine-induced thermogenesis in the rat.

@article{Preston1990AmbientTM,
  title={Ambient temperature modulation of fenfluramine-induced thermogenesis in the rat.},
  author={Edward Preston and Shi-rong Ma and Nicole Haas},
  journal={Neuropharmacology},
  year={1990},
  volume={29 3},
  pages={277-83}
}
The anti-obesity drug fenfluramine, promotes loss of weight by reducing food intake; however, there is controversy as to whether the drug can also elevate expenditure of energy. Resting consumption of oxygen (VO2) was measured in conscious rats to determine whether the injection of fenfluramine increased metabolic rate and whether prior fasting, or ambient temperature altered the response. Regardless of whether the rats were fed or had been fasted for 22 hr, in a thermoneutral environment (28… CONTINUE READING