Ambient ozone modifies the effect of tumor necrosis factor G-308A on bronchitic symptoms among children with asthma.

BACKGROUND Tumor necrosis factor (TNF)-alpha has a recognized role in respiratory pathophysiology. One genetic variant (G-308A) in the promoter region affecting the expression of this cytokine may contribute to airway inflammatory diseases, but the studies on bronchitic symptoms were still inconclusive. Because ozone produces oxidative stress, increased… CONTINUE READING