Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity.

@article{Sun2009AmbientAP,
  title={Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity.},
  author={Qinghua Sun and P. K. Yue and Jeffrey A Deiuliis and Carey N Lumeng and Thomas Kampfrath and Michael B. Mikolaj and Ying Cai and Michael C. Ostrowski and Bo Lu and Sampath Parthasarathy and Robert D. Brook and Susan D. Moffatt-Bruce and Lung-chi Chen and Sanjay Rajagopalan},
  journal={Circulation},
  year={2009},
  volume={119 4},
  pages={
          538-46
        }
}
BACKGROUND There is a strong link between urbanization and type 2 diabetes mellitus. Although a multitude of mechanisms have been proposed, there are no studies evaluating the impact of ambient air pollutants and the propensity to develop type 2 diabetes mellitus. We hypothesized that exposure to ambient fine particulate matter (<2.5 mum; PM(2.5)) exaggerates diet-induced insulin resistance, adipose inflammation, and visceral adiposity. METHODS AND RESULTS Male C57BL/6 mice were fed high-fat… CONTINUE READING
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