Amatoxin poisoning: A 15-year retrospective analysis and follow-up evaluation of 105 patients

  title={Amatoxin poisoning: A 15-year retrospective analysis and follow-up evaluation of 105 patients},
  author={Lucia Giannini and Alfredo Vannacci and Andrea Missanelli and Rosanna Mastroianni and Pier Francesco Mannaioni and Flavio Moroni and Emanuela Masini},
  journal={Clinical Toxicology},
  pages={539 - 542}
Introduction. Fatalities due to mushroom poisonings are increasing worldwide, with more than 90% of deaths resulting from ingestion of amatoxin-containing species. Methods. A retrospective evaluation of the history and clinical outcome of each patient treated from 1988 to 2002 in the Toxicological Unit of Careggi General Hospital (University of Florence, Italy) for amatoxin poisoning. Data included the biological parameters monitored, the treatment protocols used (intensive fluid and supportive… Expand
Clinical features and outcome of patients with amatoxin-containing mushroom poisoning
The factors associated with mortality determined in this retrospective study may be helpful for clinical outcome assessment and monitoring of patients with amatoxin-containing mushroom poisoning. Expand
Clinical characteristics and outcome of toxicity from Amanita mushroom poisoning
Serum transaminase and creatinine were the factors associated with death in Amanita mushroom poisoning, and treatment with oral high dose silymarin should be investigated further as one of the principal therapies in amatoxin poisoning. Expand
Mushroom poisoning in children: clinical presentation and outcome.
To start timely management, Mushroom poisoning should be considered in the differential diagnosis in patients presenting with food poisoning particularly coming in groups. Expand
A 4 Year Retrospective Analysis of Our Patients with Mushroom Poisoning
The demographic, clinical and laboratory data for the patients who presented to the emergency department (ED) of Uludag University, Faculty of Medicine between 1 January 2007 and 31 December 2010 were presented. Expand
Epidemiology and clinics of mushroom poisoning in Northern Italy: A 21-year retrospective analysis
Early identification and management of potentially life-threatening cases is challenging in the ED, so that a mycologist service on call is highly advisable, especially during periods characterized by the highest incidence of poisoning. Expand
Mushroom poisoning: a study on circumstances of exposure and patterns of toxicity.
Although pediatric exposure to mushrooms found around the home has not led to serious toxicity in this study, prevention of exposure is warranted, and inspection of wild mushrooms by a certified mushroom expert or a mycologist seems to be a safe procedure which should be recommended. Expand
Mushroom Poisoning—A 17 Year Retrospective Study at a Level I University Emergency Department in Switzerland
Presentations related to mushroom poisoning at an emergency department in Bern from January 2001 to October 2017 are described, finding mushroom poisoning does not appear to be a common reason for emergency consultation and most presentations were of minor severity and related to edible species. Expand
The onset of vomiting with the modification of the gene ral state in children from a rural area must point the anamne sis towards mushroom intoxication, even in the absence of symptoms in other family members. Expand
Amanita phalloides poisoning: Mechanisms of toxicity and treatment.
  • Juliana Garcia, V. M. Costa, +4 authors F. Carvalho
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2015
The clinical toxicology of A. phalloides is examined, providing the currently available information on the mechanisms of toxicity involved and on the current knowledge on the treatment prescribed against this type of mushrooms, to set the pace to new and improved therapy against these mushrooms. Expand
The enterohepatic circulation of amanitin: kinetics and therapeutical implications.
Amanitin disappeared almost completely from systemic and enterohepatic circulation within 24 h, suggesting that systemic detoxification and/or interrupting the entero hemostatic circulation at a later date might be poorly effective. Expand


Treatment of Amatoxin Poisoning: 20-Year Retrospective Analysis
Benzylpenicillin (Penicillin G) alone and in association was the most frequently utilized chemotherapy but showed little efficacy and future clinical research should focus on confirming the efficacy of silybin, N-acetylcysteine, and detoxication procedures. Expand
Clinical findings and follow-up evaluation of an outbreak of mushroom poisoning — survey of amanita phalloides poisoning
The results indicate that Amanita Phalloides poisoning represents a threat not only in the high mortality acute phase, but also in the development of chronic active hepatitis in some survivors. Expand
Treatment of Amanita phalloides poisoning: I. Retrospective evaluation of plasmapheresis in 21 patients.
  • S. Jander, J. Bischoff
  • Medicine
  • Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis
  • 2000
It is indicated that plasmapheresis is a safe and effective treatment for amanita phalloides poisoning but that further investigations are needed, especially involving measurements of efficacy and the efficiency of toxin removal. Expand
Amanita poisoning: a clinical-histopathological study of 64 cases of intoxication.
Amanita intoxication can also progress to chronic liver damage, and the correct evaluation of evolving liver damage involves histopathological investigations, which should be performed 6 months after the acute episode, in those patients who overcome a moderate to severe acute intoxication. Expand
Diagnostic Accuracy of Urinary Amanitin in Suspected Mushroom Poisoning: A Pilot Study
Urinary amanitin analysis is a valuable diagnostic tool and may significantly contribute to the management of suspected mushroom poisoning and at present the best diagnostic accuracy can be obtained taking advantage of both the high sensitivity and negative predictive value of the clinical assessment performed by an experienced toxicologist, and the high specificity and positive predictive value that characterize urinary aman itin analysis. Expand
Amanita poisoning: treatment and the role of liver transplantation.
The pharmacologic basis and clinical manifestations of Amanita intoxication are discussed and the rationale of various treatment modalities are outlined and a protocol that the authors believe will be useful to the clinician is summarized. Expand
Syndromic diagnosis and management of confirmed mushroom poisonings
  • J. Diaz
  • Medicine
  • Critical care medicine
  • 2005
Since the 1950s, reports of severe and fatal mushroom poisonings have increased worldwide and a new syndromic classification of mushroom poisoning is recommended to guide clinicians in making earlier diagnoses, especially in cases where only advanced critical care, including organ transplantation, may be life saving. Expand
A trend in the therapy of Amanita phalloides poisoning
A therapeutic trend which combines penicillin G infusions to the classical supportive measures was applied to 33 cases of severe A. phalloides poisoning, with 100% survival rates. Expand
The prospective value of the IPCS/EC/EAPCCT poisoning severity score in cases of poisoning.
This study demonstrates that it is useful to score telephone inquiries to a poisons information service at initial referral with the poisoning severity score, which is helpful in assessing accurately the clinical severity and the likelihood of further deterioration. Expand
Poisoning severity score. Grading of acute poisoning.
A Poisoning Severity Score has been developed and found applicable for grading the severity of poisoning and is intended to be an overall evaluation of the case, taking into account the most severe clinical features. Expand