Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice.

@article{Meisenberg1984AmastatinPT,
  title={Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice.},
  author={G Meisenberg and William Harold Michael Garth Simmons},
  journal={Peptides},
  year={1984},
  volume={5 3},
  pages={535-9}
}
Vasopressin and oxytocin cause behavioral excitation after intracerebroventricular injection in mice. This effect is short-lasting, suggesting that the peptides are rapidly inactivated in the brain. Co-injection of microgram amounts of amastatin, an aminopeptidase inhibitor, prolonged the effect of both vasopressin and oxytocin. Amastatin did not induce large vasopressin-like behavioral effects by itself, nor did it significantly potentiate the action of 1-deamino[1,6-dicarba, 8-arginine… CONTINUE READING

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