Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice

@article{Meisenberg1984AmastatinPT,
  title={Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice},
  author={G. Meisenberg and W. Simmons},
  journal={Peptides},
  year={1984},
  volume={5},
  pages={535-539}
}
Vasopressin and oxytocin cause behavioral excitation after intracerebroventricular injection in mice. This effect is short-lasting, suggesting that the peptides are rapidly inactivated in the brain. Co-injection of microgram amounts of amastatin, an aminopeptidase inhibitor, prolonged the effect of both vasopressin and oxytocin. Amastatin did not induce large vasopressin-like behavioral effects by itself, nor did it significantly potentiate the action of 1-deamino[1,6-dicarba, 8-arginine… Expand
21 Citations
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