Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice

@article{Meisenberg1984AmastatinPT,
  title={Amastatin potentiates the behavioral effects of vasopressin and oxytocin in mice},
  author={G. Meisenberg and W. H. Simmons},
  journal={Peptides},
  year={1984},
  volume={5},
  pages={535-539}
}
  • G. Meisenberg, W. H. Simmons
  • Published 1984
  • Biology, Medicine
  • Peptides
  • Vasopressin and oxytocin cause behavioral excitation after intracerebroventricular injection in mice. This effect is short-lasting, suggesting that the peptides are rapidly inactivated in the brain. Co-injection of microgram amounts of amastatin, an aminopeptidase inhibitor, prolonged the effect of both vasopressin and oxytocin. Amastatin did not induce large vasopressin-like behavioral effects by itself, nor did it significantly potentiate the action of 1-deamino[1,6-dicarba, 8-arginine… CONTINUE READING
    21 Citations

    Topics from this paper.

    Oxytocinase in the Female Rat Hypothalamus: A Novel Mechanism Controlling Oxytocin Neurones During Lactation
    • 24
    • PDF

    References

    SHOWING 1-10 OF 27 REFERENCES
    Barrel rotation induced by vasopressin and related peptides in rats
    • 117
    Behavioral effects of intracerebroventricularly administered neurohypophyseal hormone analogs in mice
    • 51
    Centrally acting peptides and tolerance to ethanol.
    • 14