Amantadine-resistant influenza A in a nursing facility.

  title={Amantadine-resistant influenza A in a nursing facility.},
  author={J Degelau and Sujata Somani and Susan L Cooper and David R. P. Guay and Kent B Crossley},
  journal={Archives of internal medicine},
  volume={152 2},
Rapid index case treatment and amantadine prophylaxis were implemented in two nursing homes exposed to influenza A. Facility A had no isolation of cases, and 18 of 22 cases occurred after amantadine hydrochloride therapy was initiated. Three patients exhibited amantadine-resistant virus. Facility B had day 1 isolation of the index case. A facility-wide outbreak did not occur. The experience of these facilities suggests that concurrent amantadine treatment and prophylaxis without adequate case… CONTINUE READING

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