Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.

  title={Amantadine inhibits NMDA receptors by accelerating channel closure during channel block.},
  author={Thomas A. Blanpied and Richard SJ Clarke and Jon W Johnson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 13},
The channel of NMDA receptors is blocked by a wide variety of drugs. NMDA receptor channel blockers include drugs of abuse that induce psychotic behavior, such as phencyclidine, and drugs with wide therapeutic utility, such as amantadine and memantine. We describe here the molecular mechanism of amantadine inhibition. In contrast to most other described channel-blocking molecules, amantadine causes the channel gate of NMDA receptors to close more quickly. Our results confirm that amantadine… CONTINUE READING
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