Amantadine in the treatment of Parkinson's disease and other movement disorders

@article{Rascol2021AmantadineIT,
  title={Amantadine in the treatment of Parkinson's disease and other movement disorders},
  author={Olivier Rascol and Margherita Fabbri and Werner Poewe},
  journal={The Lancet Neurology},
  year={2021},
  volume={20},
  pages={1048-1056}
}
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It is suggested that amantadine given as adjuvant to levodopa can markedly improve motor response complications and support the view that hyperfunction of NMDA receptors contributes to the pathogenesis oflevodopa-associated motor complications.
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TLDR
The beneficial effects of amantadine on motor response complications are maintained for at least 1 year after treatment initiation, and motor complications occurring with the patients' regular oral levodopa regimen also remained improved according to the Unified Parkinson's Disease Rating Scale (UPDRS-IV).
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It is suggested that NMDA receptor supersensitivity may contribute to the clinical expression of choreiform dyskinesias in HD and that selective antagonists at that site can safely confer palliative benefit.
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TLDR
Wash-out of amantadine in dyskinetic patients with Parkinson disease and levodopa-induced dyskinesia significantly worsened LID, and exploratory outcomes suggested that amanadine might improve apathy and fatigue in such patients.
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TLDR
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