Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease.

@article{Metman1998AmantadineAT,
  title={Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease.},
  author={Leo Verhagen Metman and Paolo Del Dotto and Pepijn van den Munckhof and John M. Fang and Maral M Mouradian and Thomas N. Chase},
  journal={Neurology},
  year={1998},
  volume={50 5},
  pages={1323-6}
}
OBJECTIVE To determine the effects of the N-methyl-D-aspartate (NMDA) antagonist amantadine on levodopa-associated dyskinesias and motor fluctuations in Parkinson's disease (PD). BACKGROUND NMDA receptor blockade can ameliorate levodopa-induced dyskinesias in primates and PD patients. Amantadine, a well-tolerated and modestly effective antiparkinsonian agent, was recently found to possess NMDA antagonistic properties. METHODS Eighteen patients with advanced PD participated in a double-blind… CONTINUE READING