Amantadine and memantine: a comprehensive review for acquired brain injury

  title={Amantadine and memantine: a comprehensive review for acquired brain injury},
  author={Heather M. Ma and Ross D. Zafonte},
  journal={Brain Injury},
  pages={299 - 315}
ABSTRACT This comprehensive review discusses clinical studies of patients following brain injuries (traumatic, acquired, or stroke), who have been treated with amantadine or memantine. Both amantadine and memantine are commonly used in the acute rehabilitation setting following brain injuries, despite their lack of FDA-approval for neuro-recovery. Given the broad utilization of such agents, there is a need to review the evidence supporting this common off-label prescribing. The purpose of this… 

Effects of Memantine in Patients with Traumatic Brain Injury: A Systematic Review

Despite laboratory and clinical evidence reporting reduced serum NSE and improved GCS, supporting the existence of the neuroprotective properties of memantine, there is a lack of reported evidence from RCTs to suggest that memantine directly leads to cognitive improvements in TBI patients.

University of Birmingham Effects of memantine in patients with traumatic brain injury

Despite laboratory and clinical evidence reporting reduced serum NSE and improved GCS, supporting the existence of the neuroprotective properties of memantine, there is a lack of reported evidence from RCTs to suggest that memantine directly leads to cognitive improvements in TBI patients.

Improvement in Memory Deficits With Memantine in Mania Secondary to Traumatic Brain Injury and Preexisting Perinatal Birth Injury

The case of a patient who presented to the hospital with symptoms suggestive of mania with psychotic features that had started after a recent TBI, with the brain scan also revealing the presence of a preexisting perinatal birth injury is presented.

Developments in treating the nonmotor symptoms of stroke

  • A. Hillis
  • Psychology, Medicine
    Expert review of neurotherapeutics
  • 2020
The strongest evidence for pharmacological intervention is in the domains of post-stroke mood disorders and epilepsy, but additional RCTs are needed to confirm the efficacy of selective serotonin reuptake inhibitors and other medications for improving recovery of cognition, language, and energy after stroke.

Amantadine: reappraisal of the timeless diamond—target updates and novel therapeutic potentials

Considering amantadine’s affinities in vitro and the expected concentration at targets at therapeutic doses in humans, the following primary targets seem to be most plausible: aromatic amino acids decarboxylase, glial-cell derived neurotrophic factor, sigma-1 receptors, phosphodiesterases, and nicotinic receptors.

Safety Considerations for the Use of Transcranial Magnetic Stimulation as Treatment for Coma Recovery in People With Severe Traumatic Brain Injury

Findings indicate a relatively safe profile for the specified rTMS protocols, however, potential for seizure induction must be monitored and future research can be broadened to include patients previously excluded on the basis of profiles raising safety concerns.

Does amantadine maintain function in long-established brain injury? A single case experimental design

A single case experimental design (SCED) trial of amantadine demonstrating improvement in function, six years following ABI is reported, believing this provides evidence for benefit of amanadine in sustaining function after ABI.

Music Stimulation for People with Disorders of Consciousness: A Scoping Review

A scoping review was carried out to identify and provide a synthesis of eligible studies published in English during the 2010–2021 period to assess the impact of music on behavioral and non-behavioral responses of people with disorders of consciousness.

Ten key reasons for continuing research on pharmacotherapy for post-stroke aphasia

The extant evidence, though limited, suggests that modulating the activity of neurotransmitter systems with pharmacological interventions is a promising strategy for ameliorating language and communication deficits in PSA.

N-methyl-D-aspartate receptor antagonists in improving cognitive deficits following traumatic brain injury: a systematic review

Although some benefits were observed, there are still some concerns regarding the efficacy and safety of NMDAR antagonists in improving post-TBI cognitive deficits.



The effects of amantadine on traumatic brain injury outcome: a double-blind, randomized, controlled, clinical trial

ABSTRACT Introduction: Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI). Methods: We performed this study as a

Placebo-controlled trial of amantadine for severe traumatic brain injury.

Amantadine accelerated the pace of functional recovery during active treatment in patients with post-traumatic disorders of consciousness, indicating a benefit with respect to the primary outcome measure.

Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review.

  • M. KrausP. Maki
  • Psychology, Medicine
    The Journal of neuropsychiatry and clinical neurosciences
  • 1997
Results of using amantadine in 7 patients with this type of symptom profile are described, and the rationale for using dopaminergics is discussed, and pertinent literature is reviewed.

Effects of Amantadine in Children with Impaired Consciousness Caused by Acquired Brain Injury: A Pilot Study

This study suggests that amantadine facilitates recovery of consciousness in pediatric acquired brain injury and provides important information necessary to design future more definitive studies.

Amantadine in Pediatric Patients with Traumatic Brain Injury: A Retrospective, Case-Controlled Study

Amantadine is a well tolerated medication when it is used in pediatric patients with traumatic brain injury, and the amantadines group showed a greater improvement in Ranchos Los Amigos level during admission, suggesting that it may be effective.

The combined use of amantadine and l-dopa/carbidopa in the treatment of chronic brain injury.

The case of a 50-year-old woman who showed persistent frontal dysfunction 5 years post-injury, who showed decreased impulsivity and perseveration and improved executive function following treatment with amantadine alone, demonstrates the potential for increasing effectiveness through a combination of dopaminergic agents.

Amantadine to enhance readiness for rehabilitation following severe traumatic brain injury

The study and its design do not support the view that amantadine has an effect on recovery of consciousness; it remains safe, inexpensive and has few side effects.

Amantadine Did Not Positively Impact Cognition in Chronic Traumatic Brain Injury: A Multi-Site, Randomized, Controlled Trial

The effect size was small and mean scores for both groups were generally within expectations for persons with history of complicated mild-to-severe TBI, suggesting that changes observed across assessments may not have functional significance.

Can Amantadine Ameliorate Neurocognitive Functions After Subarachnoid Haemorrhage? A Preliminary Study.

Compared to theStandard treatment alone, amantadine administration with the standard treatment during the early period of SAH may improve recovery and can ameliorate neurocognitive function after SAH.

Pharmaceuticals for poststroke and brain injury rehabilitation.

This issue, the first half of a four-issue special series of the American Journal of Physical Medicine & Rehabilitation, focused on innovative, physiologic treatments for stroke and traumatic brain injury, is introduced and two papers on pharmaceuticals in neurorehabilitation are presented.