Amantadine and memantine: a comprehensive review for acquired brain injury

@article{Ma2020AmantadineAM,
  title={Amantadine and memantine: a comprehensive review for acquired brain injury},
  author={Heather M. Ma and Ross D. Zafonte},
  journal={Brain Injury},
  year={2020},
  volume={34},
  pages={299 - 315}
}
ABSTRACT This comprehensive review discusses clinical studies of patients following brain injuries (traumatic, acquired, or stroke), who have been treated with amantadine or memantine. Both amantadine and memantine are commonly used in the acute rehabilitation setting following brain injuries, despite their lack of FDA-approval for neuro-recovery. Given the broad utilization of such agents, there is a need to review the evidence supporting this common off-label prescribing. The purpose of this… 
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References

SHOWING 1-10 OF 196 REFERENCES
Clinical use of amantadine in brain injury rehabilitation.
TLDR
It is suggested amantadine may play a role in neurobehavioural recovery of brain injury, and the need for more in-depth study is demonstrated.
The effects of amantadine on traumatic brain injury outcome: a double-blind, randomized, controlled, clinical trial
ABSTRACT Introduction: Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI). Methods: We performed this study as a
Placebo-controlled trial of amantadine for severe traumatic brain injury.
TLDR
Amantadine accelerated the pace of functional recovery during active treatment in patients with post-traumatic disorders of consciousness, indicating a benefit with respect to the primary outcome measure.
Effect of amantadine hydrochloride on symptoms of frontal lobe dysfunction in brain injury: case studies and review.
  • M. Kraus, P. Maki
  • Psychology, Medicine
    The Journal of neuropsychiatry and clinical neurosciences
  • 1997
TLDR
Results of using amantadine in 7 patients with this type of symptom profile are described, and the rationale for using dopaminergics is discussed, and pertinent literature is reviewed.
Effects of Amantadine in Children with Impaired Consciousness Caused by Acquired Brain Injury: A Pilot Study
TLDR
This study suggests that amantadine facilitates recovery of consciousness in pediatric acquired brain injury and provides important information necessary to design future more definitive studies.
Amantadine in Pediatric Patients with Traumatic Brain Injury: A Retrospective, Case-Controlled Study
TLDR
Amantadine is a well tolerated medication when it is used in pediatric patients with traumatic brain injury, and the amantadines group showed a greater improvement in Ranchos Los Amigos level during admission, suggesting that it may be effective.
The combined use of amantadine and l-dopa/carbidopa in the treatment of chronic brain injury.
TLDR
The case of a 50-year-old woman who showed persistent frontal dysfunction 5 years post-injury, who showed decreased impulsivity and perseveration and improved executive function following treatment with amantadine alone, demonstrates the potential for increasing effectiveness through a combination of dopaminergic agents.
Amantadine to enhance readiness for rehabilitation following severe traumatic brain injury
TLDR
The study and its design do not support the view that amantadine has an effect on recovery of consciousness; it remains safe, inexpensive and has few side effects.
Amantadine Did Not Positively Impact Cognition in Chronic Traumatic Brain Injury: A Multi-Site, Randomized, Controlled Trial
TLDR
The effect size was small and mean scores for both groups were generally within expectations for persons with history of complicated mild-to-severe TBI, suggesting that changes observed across assessments may not have functional significance.
Can Amantadine Ameliorate Neurocognitive Functions After Subarachnoid Haemorrhage? A Preliminary Study.
TLDR
Compared to theStandard treatment alone, amantadine administration with the standard treatment during the early period of SAH may improve recovery and can ameliorate neurocognitive function after SAH.
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