Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin.

@article{Schlegel1982AmantadineAD,
  title={Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin.},
  author={Richard Schlegel and Robert B. Dickson and Mark C. Willingham and Ira Pastan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 7},
  pages={
          2291-5
        }
}
The entry of many animal viruses into their host cells often proceeds via a specialized internalization pathway involving clathrin-coated regions of the plasma membrane. We have examined the effect of dansylcadaverine and amantadine on the entry of vesicular stomatitis virus (VSV) into mouse cells. Both compounds inhibit VSV entry as determined by fluorescence and electron microscopy, 3H-labeled VSV uptake, and VSV-dependent RNA synthesis assays. They also inhibit the uptake of alpha 2… CONTINUE READING
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