Amantadine: The journey from fighting flu to treating Parkinson disease

@article{Hubsher2012AmantadineTJ,
  title={Amantadine: The journey from fighting flu to treating Parkinson disease},
  author={G. Hubsher and M. Haider and M. Okun},
  journal={Neurology},
  year={2012},
  volume={78},
  pages={1096–1099}
}
Objective:To explore how amantadine transitioned from an anti-flu drug to antiparkinsonian agent. Methods:A review of the historical literature on the use of amantadine from 1966 to the present was performed. Results:Amantadine was originally introduced and utilized as an antiviral medication. A single patient noticed relief in her Parkinson disease (PD) symptoms after taking amantadine for a flu infection, and this observation sparked an interest, and several important studies that eventually… Expand
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References

SHOWING 1-10 OF 18 REFERENCES
Current pharmacotherapeutic treatment options in Parkinson's disease.
  • M. Rezak
  • Medicine
  • Disease-a-month : DM
  • 2007
  • 78
Antiviral Activity of 1-Adamantanamine (Amantadine)
  • 653
The role of serendipity in drug discovery
  • T. Ban
  • Medicine, Psychology
  • Dialogues in clinical neuroscience
  • 2006
  • 171
  • PDF
STUDIES ON THE ANTIVIRAL ACTIVITY OF AMANTADINE HYDROCHLORIDE *
  • 79
  • PDF
Drug therapies
  • Bynum WF, Porter R, eds. Companion Encyclopedia of the History of Medicine. Philadelphia: Taylor & Francis:
  • 2012
Amantadine for dyski - nesias in Parkinson ’ s disease : a randomized controlled trial
  • Dis Mon
  • 2007
Consensus on amantadine use in influenza A.
  • 6
Panel urges wide use of antiviral drug.
  • 33
...
1
2
...