Amadorins: novel post-Amadori inhibitors of advanced glycation reactions.

  title={Amadorins: novel post-Amadori inhibitors of advanced glycation reactions.},
  author={Raja G. Khalifah and John W. Baynes and Billy G Hudson},
  journal={Biochemical and biophysical research communications},
  volume={257 2},
The present review focuses on the background and progress that led to discovery of specific inhibition of post-Amadori formation of advanced glycation end products, or AGEs. The "classic" or Hodge pathway begins with glucose condensation with amino groups to form a Schiff base aldimine adduct that undergoes rearrangement to a ketoamine Amadori product. This pathway is considered an important route to AGE formation that has been implicated in glucose-mediated damage in vivo (3-5). We recently… CONTINUE READING
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