Amadori Albumin and Advanced Glycation End-Product Formation in Peritoneal Dialysis using Icodextrin

@article{Posthuma2001AmadoriAA,
  title={Amadori Albumin and Advanced Glycation End-Product Formation in Peritoneal Dialysis using Icodextrin},
  author={N. Posthuma and P. T. ter Wee and H. Niessen and A. Donker and H. Verbrugh and C. Schalkwijk},
  journal={Peritoneal Dialysis International},
  year={2001},
  volume={21},
  pages={1 - 11}
}
Objective To study the influence of peritoneal dialysis (PD) solutions on the formation of early glycated products and advanced glycation end-products (AGEs). Design and Patients The formation of both Amadori albumin and AGEs in glucose- and icodextrin-based PD fluids was analyzed in vitro and in peritoneal effluents of continuous cyclic peritoneal dialysis (CCPD) patients. Results Albumin incubated with glucose-based PD fluids showed a time- and glucose concentration-dependent formation of… Expand
Reduced systemic advanced glycation end products in children receiving peritoneal dialysis with low glucose degradation product content.
  • C. Schmitt, Dorothee von Heyl, +6 authors F. Schaefer
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2007
TLDR
GDP are rapidly absorbed from the peritoneal cavity and administration of PD solutions with low-GDP content reduces plasma AGE levels and may thus improve the cardiovascular risk profile of dialysed children. Expand
ICODEXTRIN METABOLISM IN PERITONEAL DIALYSIS: CLINICAL AND EXPERIMENTAL STUDIES
TLDR
The findings suggest that the amylase mediated oligosaccharide metabolism is altered in uremic patients, although this needs to be confirmed in larger studies, including change in daily UF, urine volume, fluid or inflammatory status. Expand
Influence of Icodextrin on Plasma and Dialysate Levels of N∊-(Carboxymethyl)Lysine and N∊-(Carboxyethyl)Lysine
Rationale Standard peritoneal glucose solutions may induce the formation of advanced glycation end products (AGEs). Preliminary data suggest that AGE formation may be less with the use of polyglucoseExpand
THE INFLUENCE OF BICARBONATE/LACTATE-BUFFERED PD FLUIDS ON Nε-(CARBOXYETHYL)LYSINE AND Nε-(CARBOXYMETHYL)LYSINE IN PERITONEAL EFFLUENT
TLDR
CEL, but not CML, in the peritoneal effluent appears to be influenced by the prescription of low GDP level fluid, probably due to the highly reduced concentration of methylglyoxal, which is needed for formation of CEL. Expand
Icodextrin: a review of its use in peritoneal dialysis.
TLDR
Icodextrin solution is effective, generally well tolerated and appears to be most useful in situations of reduced or inadequate UF with dextrose, including in high and high-average transporters, during episodes of peritonitis and patients who have failed dext rose-based dialysis. Expand
ε ε -(CARBOXYMETHYL)LYSINE AND N ε -(CARBOXYETHYL)LYSINE
⇔ Rationale: Standard peritoneal glucose solutions may induce the formation of advanced glycation end products (AGEs). Preliminary data suggest that AGE formation may be less with the use ofExpand
Glucose-Free Dialysis Solutions: Inductors of Inflammation or Preservers of Peritoneal Membrane?
TLDR
The use of glucose-free solutions, especially AA, may lead to preservation of mesothelial cell mass and host defense, however, activation of systemic and peritoneal inflammation may appear during the use of ID and to a lesser extent during use of AA. Expand
The triggering of human peritoneal mesothelial cell apoptosis and oncosis by glucose and glycoxydation products.
TLDR
Heat-sterilized PDFs that contain high glucose concentrations and GDPs, which are AGE precursors, reduce cell proliferation, induce mesothelial cell apoptosis and oncosis, and may be involved in peritoneal damage. Expand
Glucotoxicity of the peritoneal membrane: the case for VEGF.
  • A. D. De Vriese, S. Mortier, N. Lameire
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2001
TLDR
The hypothesis that the continuous exposure to the high glucose concentrations in dialysate is an important pathogenetic factor is bolstered and the recognition that glucotoxicity contributes to the development of the functional and structural changes is acknowledged. Expand
Effects of icodextrin peritoneal dialysis solution on the peritoneal membrane in the STZ-induced diabetic rat model with partial nephrectomy.
  • A. Nakao, K. Nakao, +6 authors H. Makino
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2010
TLDR
Chronic high-glucose-based PDF exposure resulted in increased vascular endothelial growth factor expression, accumulation of advanced glycation end-products (AGEs), and up-regulation of the receptor for AGE (RAGE), which were ameliorated in the icodextrin- based PDF group. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
In vitro formation of advanced glycation end products in peritoneal dialysis fluid.
TLDR
It is demonstrated that formation of AGE products occurs in dialysis fluid and that factors in dialysate can modulate this process, and that AGE formation, but not glycation, decreased as a function of the Dialysate dwell time and was inhibited by aminoguanidine. Expand
Early and advanced glycosylation end products. Kinetics of formation and clearance in peritoneal dialysis.
TLDR
Clearance of protein-associated pentosidine by the peritoneal membrane may explain lower steady state levels in patients treated by PD, yet plasma levels of the AGEpentosidine are significantly lower in PD than in hemodialysis. Expand
Advanced glycation end-products in the peritoneal fluid and in the peritoneal membrane of continuous ambulant peritoneal dialysis patients.
  • A. Mahiout, G. Ehlerding, R. Brunkhorst
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 1996
TLDR
It is concluded that there is local generation of AGE in the peritoneal membrane and a 'washing out' of A GE from the per abdomen membrane during longer dwell times, which might lead to some of the functional and morphological alterations observed after long-term CAPD. Expand
Glycation and Advanced Glycation End-Product Formation with Icodextrin and Dextrose
TLDR
Protein glycation and advanced glycation end-product formation is likely to be detrimental to peritoneal function and may contribute to loss of ultrafiltration, and more research is needed to investigate the interaction of glucose degradation products and glucose polymers with proteins. Expand
Analysis of Non Enzymatic Glycosylation In Vivo: Impact of Different Dialysis Solutions
TLDR
The data show that 4-hour Peff contents are not influenced by glucose concentration or osmolality, in contrast to GP, and suggest that long-term glucose exposure is an important determinant of membrane glycosylation. Expand
Induction of 1,2-Dicarbonyl Compounds, Intermediates in the Formation of Advanced Glycation End-Products, during Heat-Sterilization of Glucose-Based Peritoneal Dialysis Fluids
TLDR
The presence of 3-DG, MGO, and GO and possibly other dicarbonyl compounds formed during heat sterilization of glucose-based PD fluids is, to a large extent, responsible for the in vitro AGE formation by these fluids, as evidenced by the speed of A GE formation in PD fluids and the complete inhibition by aminoguanidine. Expand
3-Deoxyglucosone, a Promoter of Advanced Glycation end Products in Fluids for Peritoneal Dialysis
TLDR
It is speculated that the presence of 3-DG in unused conventional PD-fluid could act as a local promoter, and increase local AGE formation within the peritoneal cavity. Expand
Nonenzymatically glycated albumin (Amadori adducts) enhances nitric oxide synthase activity and gene expression in endothelial cells.
TLDR
The data indicate that Amadori products of glycated albumin modulate NO synthase activity and eicosanoid balance in EC, and may be relevant to the hemodynamic changes in the early phases of diabetic nephropathy and in the lasting progression to sclerosis. Expand
Clearance of pentosidine, an advanced glycation end product, by different modalities of renal replacement therapy.
TLDR
The findings demonstrate that both HD and CAPD remove Pfree; the peritoneal clearance of Palb, might contribute to the lower level of plasma pentosidine in CAPD than in HD patients; and renal transplantation is the best therapeutic modality to normalize both Palb and Pfree levels. Expand
Amadori albumin in type 1 diabetic patients: correlation with markers of endothelial function, association with diabetic nephropathy, and localization in retinal capillaries.
TLDR
The results are consistent with a proposed pathophysiological role of Amadori albumin in microvascular complications of type 1 diabetic patients. Expand
...
1
2
3
4
...