Amadori‐glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells

@article{Oak2003AmadoriglycatedPI,
  title={Amadori‐glycated phosphatidylethanolamine induces angiogenic differentiations in cultured human umbilical vein endothelial cells},
  author={Jeong‐Ho Oak and Kiyotaka Nakagawa and Shin'ichi Oikawa and Teruo Miyazawa},
  journal={FEBS Letters},
  year={2003},
  volume={555}
}
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TLDR
This study synthesized the Amadori products derived from the glycation of phosphatidylethanolamine (PE) using solid phase extraction followed by HPLC, and testing biological materials showedAmadori-PE (Glc-PE) was detectable in rat plasma.
Glucosylated glycerophosphoethanolamines are the major LDL glycation products and increase LDL susceptibility to oxidation: evidence of their presence in atherosclerotic lesions.
TLDR
Inclusion of glucosylated phosphatidylethanolamine in the surface lipid monolayer of the LDL resulted in rapid loss of polyunsaturated cholesteryl esters from the interior of the particle during oxidation.
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