Amadori‐glycated phosphatidylethanolamine up‐regulates telomerase activity in PANC‐1 human pancreatic carcinoma cells

@article{Eitsuka2012AmadoriglycatedPU,
  title={Amadori‐glycated phosphatidylethanolamine up‐regulates telomerase activity in PANC‐1 human pancreatic carcinoma cells},
  author={Takahiro Eitsuka and Kiyotaka Nakagawa and Yuichi Ono and Naoto Tatewaki and Hiroshi Nishida and Tadao Kurata and Naoki Shoji and Teruo Miyazawa},
  journal={FEBS Letters},
  year={2012},
  volume={586}
}
Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
TLDR
A few dietary components, including genistein and glycated lipid, induce cellular telomerase activity in several types of cancer cells, suggesting that they may be involved in tumor progression.
Comprehensive Identification of Amadori Compound-Modified Phosphatidylethanolamines in Human Plasma.
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Activators of the innate immune toll-like receptor (TLR)-4 signaling have been proved as essential mediators in hepatocellular carcinoma promotion and other cell surface clusters of differentiation play important roles in leukocyte guidance and metastatic penetrance and tumor growth.
A UPLC-MRM-MS method for comprehensive profiling of Amadori compound-modified phosphatidylethanolamines in human plasma
TLDR
This work extends identification of Amadori-PE to the low-abundance species, which is facilitated by using plasma lipids glycated in vitro, and improves confidence of identification by high-resolution tandem mass spectrometry and chromatographic retention time regression.
The bidirectional interation between pancreatic cancer and diabetes
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The discovery of biomarkers for the early diagnosis of PanCa, as well as the novel usage of metformin for its antitumor effects and determining the potential mechanisms of these effects, may be the next direction for PanCa research and treatment.
Review of the formation and influencing factors of food-derived glycated lipids
TLDR
In this review, potentially harmful effect, distribution, formation environment and mechanism, and determination and inhibitory methods of glycated lipids are presented and contribute to the final control of food-derived glycatedlipids.
Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.

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