Amadori‐glycated phosphatidylethanolamine up‐regulates telomerase activity in PANC‐1 human pancreatic carcinoma cells

  title={Amadori‐glycated phosphatidylethanolamine up‐regulates telomerase activity in PANC‐1 human pancreatic carcinoma cells},
  author={Takahiro Eitsuka and Kiyotaka Nakagawa and Yuichi Ono and Naoto Tatewaki and Hiroshi Nishida and Tadao Kurata and Naoki Shoji and Teruo Miyazawa},
  journal={FEBS Letters},
Modulation of Telomerase Activity in Cancer Cells by Dietary Compounds: A Review
A few dietary components, including genistein and glycated lipid, induce cellular telomerase activity in several types of cancer cells, suggesting that they may be involved in tumor progression.
Comprehensive Identification of Amadori Compound-Modified Phosphatidylethanolamines in Human Plasma.
Amadori compound modified lipids are the result of nonenzymatic glycation and play an important role in several physiological and pathological processes. However, glycation of
Immunonutritional Bridge to Liver Health
Activators of the innate immune toll-like receptor (TLR)-4 signaling have been proved as essential mediators in hepatocellular carcinoma promotion and other cell surface clusters of differentiation play important roles in leukocyte guidance and metastatic penetrance and tumor growth.
A UPLC-MRM-MS method for comprehensive profiling of Amadori compound-modified phosphatidylethanolamines in human plasma
This work extends identification of Amadori-PE to the low-abundance species, which is facilitated by using plasma lipids glycated in vitro, and improves confidence of identification by high-resolution tandem mass spectrometry and chromatographic retention time regression.
The bidirectional interation between pancreatic cancer and diabetes
The discovery of biomarkers for the early diagnosis of PanCa, as well as the novel usage of metformin for its antitumor effects and determining the potential mechanisms of these effects, may be the next direction for PanCa research and treatment.
Review of the formation and influencing factors of food-derived glycated lipids
In this review, potentially harmful effect, distribution, formation environment and mechanism, and determination and inhibitory methods of glycated lipids are presented and contribute to the final control of food-derived glycatedlipids.
Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.


Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3.
It is reported here that physiologically achievable concentrations of genistein enhance telomerase activity, the proliferation of human prostate cancer cells and tumor growth in the transgenic adenocarcinoma mouse prostate model.
Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer.
Findings provide strong evidence that expression of hTRT is a rate-limiting determinant of the enzymatic activity of human telomerase and that up-regulation of h TRT expression may play a critical role in human carcinogenesis.
Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells?
Conjugated eicosapentaenoic acid and CDHA with triene structure showed intensive cytotoxicity with LD(50) at 12 and 16 microM, respectively, in DLD-1 cells, while they had no effect on normal human fibroblast cell lines such as MRC-5, TIG-103, and KMS-6 cells.
Low molecular weight inhibitors of Myc–Max interaction and function
The results show that the yeast two-hybrid screen is useful for identifying compounds that can be exploited in mammalian cells and provides a means by which structural analogs, based upon these first-generation Myc–Max inhibitors, can be developed to enhance antitumor efficacy.