Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast.

@article{Cooper2000Ama1pIA,
  title={Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast.},
  author={Katrina F Cooper and Michael J. Mallory and Daniel B. Egeland and Michal Jarnik and Randy Strich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 26},
  pages={14548-53}
}
Meiosis is the developmental program by which diploid organisms produce haploid gametes capable of sexual reproduction. Here we describe the yeast gene AMA1, a new member of the Cdc20 protein family that regulates the multisubunit ubiquitin ligase termed the anaphase promoting complex/cyclosome (APC/C). AMA1 is developmentally regulated in that its transcription and splicing occur only in meiotic cells. The meiosis-specific processing of AMA1 mRNA depends on the previously described MER1… CONTINUE READING
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