Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition

@article{Oikawa2010AlzheimertypeTP,
  title={Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition},
  author={Naoto Oikawa and Nobuyuki Kimura and Katsuhiko Yanagisawa},
  journal={Brain Research},
  year={2010},
  volume={1315},
  pages={137-149}
}
We elucidated how Alzheimer-type pathologies of amyloid beta-protein (Abeta) and tau spatiotemporally emerge in brains of nontransgenic nonhuman primate, cynomolgus monkey, in the present study. To examine the accumulation of deposited Abeta, phosphorylated tau accumulation, intracellular tau accumulation, and neurofibrillary tangle formation, the brains, mainly temporal cortex and hippocampus, of 34 cynomolgus monkeys aged 6 to 36 years were studied by biochemical and histochemical analyses… CONTINUE READING

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