Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease.

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@article{Hyman1994AlzheimersDI, title={Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease.}, author={Bradley T. Hyman and Teresa G{\'o}mez-Isla}, journal={Neurobiology of aging}, year={1994}, volume={15 3}, pages={353-4; discussion 379-80} }